NTD – Communicable Diseases Research

Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domain

SARS-CoV-2 S2 도메인에 대한 항체의 결합 및 중화 능력

Article

Published on 2022-11-302022-09-11
Journal: Human vaccines & immunotherapeutics
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2

Article

Published on 2022-11-012022-11-15
Journal: Cellular and Molecular Immunology
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened
[DOI] 10.1038/s41423-022-00924-8 PMC 바로가기

Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey

Article

Published on 2022-10-262022-11-15
Journal: mBio
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] acute respiratory syndrome antibody antibody resistance attack rate B.1.351 B.1.526 Care caused characteristic Clinical use collected Community Complete coronavirus COVID-19 Critical E484K mutation Evidence Examining exhibit exhibited hcp Health highlight individual infected individuals Infection Inpatient Lineage loss of activity monoclonal antibody Mutation N-terminal domain neutralization capacity Neutralizing antibody response neutralizing capacity New nosocomial NTD outbreak P.1 Patient plasma positive professional professionals proportion pseudovirus psychiatric facility Receptor binding domain reported reverse transcription robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein Symptom symptomatic COVID-19 disease tested the SARS-CoV-2 the United State treat vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern variants of concern. VOCs wild type
[DOI] 10.1128/mbio.02141-22 PMC 바로가기

Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated Individuals

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 진단,

[키워드] ACE-2 ACE2 ACE2 binding analyzed Angiotensin converting enzyme-2 Anti-RBD IgG Anti-spike anti-spike antibody anti-Spike IgG antibody binding blood collection BNT162b2 calculated collected Concentration correlated correlation correlation coefficient correlation coefficients COVID-19 COVID-19 antibody demonstrated dosing interval examined Fisher group groups IgG individual inhibition interval intervals labor-intensive measure mRNA mRNA-1273 vaccines Neutralizing antibodies neutralizing antibodies. neutralizing antibody Neutralizing antibody titer neutralizing antibody titers NTD Participants performed RBD Sample SARS-CoV-2 Secondary analyses Spearman correlation coefficient subgroup tested the median the vaccine titer vaccinated individual vaccination Vaccine vaccinee vaccinees Validity viral neutralization wild-type with COVID-19 women
[DOI] 10.1128/spectrum.01315-22 PMC 바로가기

Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike

Article

Published on 2022-10-062022-11-16
Journal: EMBO Reports
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessment

SARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가

Article

Published on 2022-10-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2. sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type
[DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article

A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion system

Article

Published on 2022-10-012022-11-15
Journal: Journal of Applied Microbiology
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,

[키워드] administration Analysis antibody Antigen antigens attenuated Salmonella ΔhtrA-VNP Bacterial caused CD44 CD69 COVID-19 vaccine cytometric cytosol delivery effective element elicited Express expression Flow fluorescence microscopy Heterologous IgA IgG in vitro increase in Macrophage mixed bacterial preparations. mutant N-protein NTD Oral vaccine pathogenicity phenotype Plasmid promoter RBD S-protein Safe Salmonella SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine screened secrete secretion shown Significance Significant significant increase SPI-2 strain T-cell activation T3SS the vaccine type III Vaccine was used
[DOI] 10.1111/jam.15720 PMC 바로가기

Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticals

Article

Published on 2022-10-012022-11-15
Journal: Journal of food biochemistry
[Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex Complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened
[DOI] 10.1111/jfbc.14262 PMC 바로가기

Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2

Article

Published on 2022-09-162022-11-15
Journal: Viruses
[Category] SARS, 진단,

COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccine

Article

Published on 2022-09-092022-11-15
Journal: PLoS ONE
[Category] SARS, 변종, 진단,

[키워드] ACE2 Ageusia angiotensin-converting enzyme 2 Anosmia Antibody Response Antibody titer blood sample Clinical characteristics Cook County Health cough COVID-19 immunity COVID-19 symptom COVID-19 vaccine D614G demographics dependent on evaluated Fever health system humoral IC50 immune response Immunity Infection less magnitude mRNA BNT162b2 mutant N-terminal domain neutralization NTD participant PCR-confirmed positive Post-infection Prevent Primary infection Protein provided RBD Receptor binding domain Reinfection reported symptoms SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 test severity significantly significantly higher spike subsequent Symptom Symptoms the antibody response the spike protein these symptoms vaccination
[DOI] 10.1371/journal.pone.0273323 PMC 바로가기